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Two French surgeons, Joseph Malgaigne and Germanicus Mirault, dissatisfied with the inevitable postoperative contracture of the straight-line lip repair and resulting whistling deformity, were among the first to develop alternative repairs

Cyanocobalamin is an active, easily absorbable form of B12 that corrects deficiencies and supports vital biological functions: nerve health, red blood cell formation, cell metabolism, and DNA synthesis

The five-step study framework of this CEA is illustrated in Additional file 1: Fig